What is Cannabigerol (CBG)?

What is Cannabigerol (CBG)?

What is CBG?

The cannabis plant produces hundreds of cannabinoids. The pharmacology of most of these have yet to be studied. More common cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD) have a long history and awareness. With the passing of the 2018 Farm Bill and the country wide cultivation of hemp, lesser know cannabinoids have be gaining attention as more research is allowed. Cannabigerol (CBG) was first detected in 1964 and found to not contain similar hallucinogenic properties as THC. CBG is the known precursor to THC and CBD and is abundantly found in some hemp varieties. Because CBG is the precursor to THC and CBD, it can provide the beneficial properties of cannabinoids without the worry of THC concentration.

What Does CBG Do?

In vitro studies show that CBG can counteract oxidative stress by activation of CB2 receptors. Anti-inflammatory and neuroprotective effects were also reported for CBG in vitro and in vivo in neurodegenerative disease models making it a compound of focus for future studies of neurodegenerative disorders. Inflammation and oxidative stress are key factors in neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease and multiple sclerosis. There is no known cure for neurodegenerative disorders, however there is an array of research focused on the discovery of new compounds that may be able to delay or prevent the degradation of neuronal cells. Compounds with both anti-inflammatory and antioxidative properties may provide a strategy to protect neuronal cells.

Where Does CBG Come From?

Like CBD, CBG is derived from the cannabis sativa plant. The cannabinoid composition produced by the plant depends on the metabolic pathways that convert precursor cannabinoids to end product cannabinoids. The different conversions of CBG are enzymatically catalyzed by THC-synthase and CBD-synthase. Plants accumulating the precursor CBG are presumed to contain a single mutation which leads to dysfunctional synthases.

 

Written by: Joshua Baez

 

References

de Meijer, E., & Hammond, K. (2005). The Inheritance of chemical phenotype in Cannabis sativa L.: Cannabigerol predominant plants. Euphytica, 189-198.

Gaoni Y, M. R. (1964). Hashish II: The structure and synthesis of cannabigerol, a new hashish constituent. Proc Chem Soc, 82.

Garcia, C., Gomez-Canas, M., Burgaz, S., Palomares, B., Gomez-Galvez, Y., Palomo-Garo, C., . . . al., e. (2018). A cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental parkinson's disease: Possible involvement of different binding sites at the pargamma receptor. Neuroinflamm, 15-19.

Giacoppo, S., Gugliandolo, A., Trubiani, O., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2017). Cannabinoid CB2 receptors are involved in the protection of raw264.7 macrophages against oxidative stress: An in vitro study. European Journal of Histochemistry, 61.

Granja AG, C.-S. F. (2012). A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis. J Neuroimmune Pharmacol, 1002-1016.

Mammana, S., Cavalli, E., Gugliandolo, A., Silvestro, S., Pollastro, F., Bramanti, P., & Mazzon, E. (2019). Could the combination of two Non-psychotropic Cannabinoids counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol. . Medicina, 55.

 

Comments 0

Leave a comment